Since 2005, this study has regulary compared Canadian and American retail prices for an identical group of the 100 most commonly prescribed brand-name (mostly patented) drugs and the 100 most commonly prescribed generic drugs in Canada. This year?s study focuses exclusively on the price difference between the two countries for the 100 generic drugs that were most commonly prescribed in Canada in 2008. The analysis replicates the same methodology that was used in previous editions (Skinner, 2005;Skinner and Rovere, 2007; Skinnerand Rovere, 2008) making the results comparable to those reports.