Several major cities including Windsor and Thunder Bay experienced a rate of job creation below the national average.
Total business investment declined by 0.2 per cent per year between 2016 and 2019.
Michigan replaced its complex business tax with a flat corporate income tax of 6 per cent.
Women over 25 years old working full-time were hardest hit, with employment decreasing by 31,500 jobs.
Only New Brunswick and Nova Scotia created fewer private-sector jobs than Ontario, on average, each year between 2007 and 2016.
In northern Ontario, job losses ranged from 1 per cent in Greater Sudbury to 16.1 per cent in Sault Ste. Marie.
The Brown-led PCs would move to a $15 minimum wage over a four-year period.
Current projections suggest firms will invest less money in Ontario this year than in 2008.